BDBM757866 (S)-6-(5-azaspiro[2.4]heptan-5- ylmethyl)-2-(3-(1-(fluoro(4-methyl-4H- 1,2,4-triazol-3- yl)methyl)cyclopropyl)phenyl)-4- (trifluoromethyl)isoindolin-1-one::US20250230147, Compound 28

SMILES Cn1cnnc1[C@@H](F)C1(c2cccc(N3Cc4c(cc(CN5CCC6(CC6)C5)cc4C(F)(F)F)C3=O)c2)CC1

InChI Key InChIKey=MHRNWJMAZZPZKN-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 757866   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 757866BDBM757866((S)-6-(5-azaspiro[2.4]heptan-5- ylmethyl)-2-(3-(1-...)
Affinity DataIC50: 80nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 757866BDBM757866((S)-6-(5-azaspiro[2.4]heptan-5- ylmethyl)-2-(3-(1-...)
Affinity DataIC50: 180nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent