BDBM757868 (R)-2-(3-(1-(fluoro(4-methyl-4H-1,2,4- triazol-3-yl)methyl)cyclopropyl)phenyl)- 6-((3-hydroxy-3-methylazetidin-1- yl)methyl)-4-(trifluoromethyl)isoindolin- 1-one::US20250230147, Compound 30

SMILES Cn1cnnc1[C@H](F)C1(c2cccc(N3Cc4c(cc(CN5CC(C)(O)C5)cc4C(F)(F)F)C3=O)c2)CC1

InChI Key InChIKey=AHJICCNMPMAJSN-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 757868   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 757868BDBM757868((R)-2-(3-(1-(fluoro(4-methyl-4H-1,2,4- triazol-3-y...)
Affinity DataIC50: 65nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 757868BDBM757868((R)-2-(3-(1-(fluoro(4-methyl-4H-1,2,4- triazol-3-y...)
Affinity DataIC50: 91nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent