BDBM758024 2-(3-(3-((R)-fluoro(4-methyl-4H-1,2,4- triazol-3-yl)methyl)oxetan-3-yl)phenyl)- 6-(((S)-2-isopropyl-4-(2,2,2- trifluoroethyl)piperazin-1-yl)methyl)-4- (trifluoromethyl)isoindolin-1-one::US20250230147, Compound 202

SMILES CC(C)[C@H]1CN(CC(F)(F)F)CCN1Cc1cc2c(c(C(F)(F)F)c1)CN(c1cccc(C3([C@@H](F)c4nncn4C)COC3)c1)C2=O

InChI Key InChIKey=MPSOHKRKVFXVQI-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 758024   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758024BDBM758024(2-(3-(3-((R)-fluoro(4-methyl-4H-1,2,4- triazol-3-y...)
Affinity DataIC50: 150nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758024BDBM758024(2-(3-(3-((R)-fluoro(4-methyl-4H-1,2,4- triazol-3-y...)
Affinity DataIC50: 400nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent