BDBM758044 (S)-6-((2-Isopropyl-4-methylpiperazin- 1-yl)methyl)-2-(3-(3-((5-methyl-1H- 1,2,3-triazol-1-yl)methyl)oxetan-3- yl)phenyl)-4-(trifluoromethyl)isoindolin- 1-one::US20250230147, Compound 222

SMILES Cc1cnnn1CC1(c2cccc(N3Cc4c(cc(CN5CCN(C)C[C@@H]5C(C)C)cc4C(F)(F)F)C3=O)c2)COC1

InChI Key InChIKey=VNEAYSIBGHYEBM-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 758044   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758044BDBM758044((S)-6-((2-Isopropyl-4-methylpiperazin- 1-yl)methyl...)
Affinity DataIC50: 22nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758044BDBM758044((S)-6-((2-Isopropyl-4-methylpiperazin- 1-yl)methyl...)
Affinity DataIC50: 26nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent