BDBM758100 (S)-4-chloro-2-(3-(3,3-difluoro-1-((4- methyl-4H-1,2,4-triazol-3- yl)methyl)cyclobutyl)phenyl)-6-((2- isopropyl-4-methylpiperazin-1- yl)methyl)isoindolin-1-one::US20250230147, Compound 281

SMILES CC(C)[C@H]1CN(C)CCN1Cc1cc(Cl)c2c(c1)C(=O)N(c1cccc(C3(Cc4nncn4C)CC(F)(F)C3)c1)C2

InChI Key InChIKey=VSHHNQWTMJPRNY-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 758100   

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758100BDBM758100((S)-4-chloro-2-(3-(3,3-difluoro-1-((4- methyl-4H-1...)
Affinity DataIC50: 11nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758100BDBM758100((S)-4-chloro-2-(3-(3,3-difluoro-1-((4- methyl-4H-1...)
Affinity DataIC50: 16nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent