BDBM758127 3-((4-(1-((4-methyl-4H-1,2,4-triazol-3- yl)methyl)cyclobutyl)-6-(6-(((1- methylcyclobutyl)amino)methyl)-1-oxo- 4-(trifluoromethyl)isoindolin-2- yl)pyridin-2-yl)amino)propanenitrile::US20250230147, Compound 308

SMILES Cn1cnnc1CC1(c2cc(NCCC#N)nc(N3Cc4c(cc(CNC5(C)CCC5)cc4C(F)(F)F)C3=O)c2)CCC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 758127   

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandPNGBDBM758127(3-((4-(1-((4-methyl-4H-1,2,4-triazol-3- yl)methyl)...)
Affinity DataIC50: 7.5nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandPNGBDBM758127(3-((4-(1-((4-methyl-4H-1,2,4-triazol-3- yl)methyl)...)
Affinity DataIC50: 12nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent