BDBM758130 N,N-dimethyl-2-((4-(1-((4-methyl-4H- 1,2,4-triazol-3-yl)methyl)cyclobutyl)-6- (6-(((1-methylcyclobutyl)amino)methyl)- 1-oxo-4-(trifluoromethyl)isoindolin-2- yl)pyridin-2-yl)amino)acetamide formate::US20250230147, Compound 311

SMILES CN(C)C(=O)CNc1cc(C2(Cc3nncn3C)CCC2)cc(N2Cc3c(cc(CNC4(C)CCC4)cc3C(F)(F)F)C2=O)n1

InChI Key InChIKey=YJCSZLHOZYFGSF-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 758130   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758130BDBM758130(N,N-dimethyl-2-((4-(1-((4-methyl-4H- 1,2,4-triazol...)
Affinity DataIC50: 110nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758130BDBM758130(N,N-dimethyl-2-((4-(1-((4-methyl-4H- 1,2,4-triazol...)
Affinity DataIC50: 140nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent