BDBM758233 2-(3-(3,3-difluoro-1-((4-methyl-4H- 1,2,4-triazol-3- yl)methyl)cyclobutyl)phenyl)-6- (((1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)methyl)- 4-(trifluoromethyl)isoindolin-1-one::US20250230147, Compound 414

SMILES CN1C[C@@H]2C[C@H]1CN2Cc1cc2c(c(C(F)(F)F)c1)CN(c1cccc(C3(Cc4nncn4C)CC(F)(F)C3)c1)C2=O

InChI Key InChIKey=SGBZZVGRFHQTDY-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 758233   

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758233BDBM758233(2-(3-(3,3-difluoro-1-((4-methyl-4H- 1,2,4-triazol-...)
Affinity DataIC50: 68nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758233BDBM758233(2-(3-(3,3-difluoro-1-((4-methyl-4H- 1,2,4-triazol-...)
Affinity DataIC50: 88nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent