BDBM758259 (S)-2-(3-(3,3-difluoro-1-((4-methyl-4H- 1,2,4-triazol-3- yl)methyl)cyclobutyl)phenyl)-6-((3- hydroxy-3-methylpiperidin-1-yl)methyl)- 4-(trifluoromethyl)isoindolin-1-one::US20250230147, Compound 440

SMILES Cn1cnnc1CC1(c2cccc(N3Cc4c(cc(CN5CCC[C@](C)(O)C5)cc4C(F)(F)F)C3=O)c2)CC(F)(F)C1

InChI Key InChIKey=WPZZBQUGXKJVHA-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 758259   

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758259BDBM758259((S)-2-(3-(3,3-difluoro-1-((4-methyl-4H- 1,2,4-tria...)
Affinity DataIC50: 110nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758259BDBM758259((S)-2-(3-(3,3-difluoro-1-((4-methyl-4H- 1,2,4-tria...)
Affinity DataIC50: 140nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent