BDBM758272 (S)-6-(amino(cyclopropyl)methyl)-2-(3- (3,3-difluoro-1-((4-methyl-4H-1,2,4- triazol-3-yl)methyl)cyclobutyl)phenyl)-4- (trifluoromethyl)isoindolin-1-one::US20250230147, Compound 453

SMILES Cn1cnnc1CC1(c2cccc(N3Cc4c(cc([C@@H](N)C5CC5)cc4C(F)(F)F)C3=O)c2)CC(F)(F)C1

InChI Key InChIKey=YXGTUEJNMDXGKP-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 758272   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758272BDBM758272((S)-6-(amino(cyclopropyl)methyl)-2-(3- (3,3-difluo...)
Affinity DataIC50: 14nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758272BDBM758272((S)-6-(amino(cyclopropyl)methyl)-2-(3- (3,3-difluo...)
Affinity DataIC50: 18nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent