BDBM758275 2-(3-(isopropylamino)-5-(1-((4-methyl- 4H-1,2,4-triazol-3- yl)methyl)cyclobutyl)phenyl)-6- ((propylamino)methyl)-4- (trifluoromethyl)isoindolin-1-one::US20250230147, Compound 456

SMILES CCCNCc1cc2c(c(C(F)(F)F)c1)CN(c1cc(NC(C)C)cc(C3(Cc4nncn4C)CCC3)c1)C2=O

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 758275   

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandPNGBDBM758275(2-(3-(isopropylamino)-5-(1-((4-methyl- 4H-1,2,4-tr...)
Affinity DataIC50: 7.60nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandPNGBDBM758275(2-(3-(isopropylamino)-5-(1-((4-methyl- 4H-1,2,4-tr...)
Affinity DataIC50: 13nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent