BDBM758286 (1r,3r)-3-((4-methyl-4H-1,2,4-triazol-3- yl)methyl)-3-(3-(6-(((1- methylcyclobutyl)amino)methyl)-1-oxo- 4-(trifluoromethyl)isoindolin-2- yl)phenyl)cyclobutanecarbonitrile::US20250230147, Compound 467

SMILES Cn1cnnc1C[C@]1(c2cccc(N3Cc4c(cc(CNC5(C)CCC5)cc4C(F)(F)F)C3=O)c2)C[C@H](C#N)C1

InChI Key InChIKey=GBIDRKRHZFNOOR-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 758286   

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758286BDBM758286((1r,3r)-3-((4-methyl-4H-1,2,4-triazol-3- yl)methyl...)
Affinity DataIC50: 11nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758286BDBM758286((1r,3r)-3-((4-methyl-4H-1,2,4-triazol-3- yl)methyl...)
Affinity DataIC50: 12nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent