BDBM758306 2-(3-(3-((S)-(4-cyclopropyl-4H-1,2,4- triazol-3-yl)fluoromethyl)oxetan-3- yl)phenyl)-6-(((S)-2-isopropyl-4- methylpiperazin-1-yl)methyl)-4- (trifluoromethyl)isoindolin-1-one::US20250230147, Compound 487

SMILES CC(C)[C@H]1CN(C)CCN1Cc1cc2c(c(C(F)(F)F)c1)CN(c1cccc(C3([C@H](F)c4nncn4C4CC4)COC3)c1)C2=O

InChI Key InChIKey=XRDFEJQMLYRLHE-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 758306   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758306BDBM758306(2-(3-(3-((S)-(4-cyclopropyl-4H-1,2,4- triazol-3-yl...)
Affinity DataIC50: 1.80E+3nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758306BDBM758306(2-(3-(3-((S)-(4-cyclopropyl-4H-1,2,4- triazol-3-yl...)
Affinity DataIC50: 2.70E+3nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent