BDBM758312 2-(6-(bicyclo[2.1.1]hexan-1-ylamino)-4- (3-((4-methyl-4H-1,2,4-triazol-3- yl)methyl)oxetan-3-yl)pyridin-2-yl)-4- (trifluoromethyl)isoindolin-1-one::US20250230147, Compound 493

SMILES Cn1cnnc1CC1(c2cc(NC34CCC(C3)C4)nc(N3Cc4c(cccc4C(F)(F)F)C3=O)c2)COC1

InChI Key InChIKey=RWPYDHNORQWPEZ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 758312   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758312BDBM758312(2-(6-(bicyclo[2.1.1]hexan-1-ylamino)-4- (3-((4-met...)
Affinity DataIC50: 630nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758312BDBM758312(2-(6-(bicyclo[2.1.1]hexan-1-ylamino)-4- (3-((4-met...)
Affinity DataIC50: 4.50E+3nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent