BDBM758704 4-(5-cyano-2-methoxyphenyl)-6- methyl-N-(5-(N-(2,2,2- trifluoroethyl)sulfamoyl)-5,6-dihydro- 4H-pyrrolo[3,4-d]thiazol-2- yl)nicotinamide::US20250230171, Compound 272

SMILES COc1ccc(C#N)cc1-c1cc(C)ncc1C(=O)Nc1nc2c(s1)CN(S(=O)(=O)NCC(F)(F)F)C2

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 758704   

TargetDNA polymerase theta (POLQ) (2-894)(Human)
Moma Therapeutics

US Patent
LigandPNGBDBM758704(4-(5-cyano-2-methoxyphenyl)-6- methyl-N-(5-(N-(2,2...)
Affinity DataIC50: 8nMAssay Description:POLθ-mediated ATP hydrolysis was measured using the ADP-Glo Kinase Assay (Promega Corporation, Madison, WI). Reactions were performed in white 384-we...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent