BDBM759185 8-bromo-7-chloro-2-(difluoromethyl)-6-(2,6-difluorophenyl)-4H-benzo[f]imidazo[1,2-a][1,4]diazepine::US12365687, Example 3

SMILES Fc1cccc(F)c1C1=NCc2nc(C(F)F)cn2-c2ccc(Br)c(Cl)c21

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 759185   

LigandPNGBDBM759185(8-bromo-7-chloro-2-(difluoromethyl)-6-(2,6-difluor...)
Affinity DataKi:  1.28nMAssay Description:Table 1 and 3: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]Fluma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

LigandPNGBDBM759185(8-bromo-7-chloro-2-(difluoromethyl)-6-(2,6-difluor...)
Affinity DataKi:  30.2nMAssay Description:Table 2: Electrophysiological experiments were performed using the Roboocyte instrument (MultiChannelSystems, Reutlingen, Germany) on days 3 to 5 aft...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

LigandPNGBDBM759185(8-bromo-7-chloro-2-(difluoromethyl)-6-(2,6-difluor...)
Affinity DataKi:  30.2nMAssay Description:Table 1 and 3: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]Fluma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

LigandPNGBDBM759185(8-bromo-7-chloro-2-(difluoromethyl)-6-(2,6-difluor...)
Affinity DataKi:  455nMAssay Description:Table 1 and 3: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]Fluma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent