BDBM759206 [7,8-dichloro-6-(2,6-difluorophenyl)-4H-[1,2,4]triazolo[1,5-a][1,4]benzodiazepin-2-yl]-(3-hydroxyazetidin-1-yl)methanone::US12365687, Example 24

SMILES O=C(c1nc2n(n1)-c1ccc(Cl)c(Cl)c1C(c1c(F)cccc1F)=NC2)N1CC(O)C1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 759206   

LigandPNGBDBM759206([7,8-dichloro-6-(2,6-difluorophenyl)-4H-[1,2,4]tri...)
Affinity DataKi:  0.450nMAssay Description:Table 1 and 3: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]Fluma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

LigandPNGBDBM759206([7,8-dichloro-6-(2,6-difluorophenyl)-4H-[1,2,4]tri...)
Affinity DataKi:  3.10nMAssay Description:Table 2: Electrophysiological experiments were performed using the Roboocyte instrument (MultiChannelSystems, Reutlingen, Germany) on days 3 to 5 aft...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

LigandPNGBDBM759206([7,8-dichloro-6-(2,6-difluorophenyl)-4H-[1,2,4]tri...)
Affinity DataKi:  3.14nMAssay Description:Table 1 and 3: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]Fluma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

LigandPNGBDBM759206([7,8-dichloro-6-(2,6-difluorophenyl)-4H-[1,2,4]tri...)
Affinity DataKi:  273nMAssay Description:Table 1 and 3: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]Fluma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent