BDBM759245 (4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-N-[(2S)-2-hydroxypropyl]-4H-[1,2,4]triazolo[1,5-a][1,4]benzodiazepine-2-carboxamide::US12365687, Example 63

SMILES C[C@H](O)CNC(=O)c1nc2n(n1)-c1ccc(Cl)c(Cl)c1C(c1c(F)cccc1F)=N[C@H]2C

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 759245   

LigandPNGBDBM759245((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...)
Affinity DataKi:  1.33nMAssay Description:Table 1 and 3: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]Fluma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

LigandPNGBDBM759245((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...)
Affinity DataKi:  4.20nMAssay Description:Table 2: Electrophysiological experiments were performed using the Roboocyte instrument (MultiChannelSystems, Reutlingen, Germany) on days 3 to 5 aft...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

LigandPNGBDBM759245((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...)
Affinity DataKi:  4.25nMAssay Description:Table 1 and 3: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]Fluma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

LigandPNGBDBM759245((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...)
Affinity DataKi:  606nMAssay Description:Table 1 and 3: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]Fluma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent