BDBM759247 (4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-N-[(2R)-2-hydroxypropyl]-4H-[1,2,4]triazolo[1,5-a][1,4]benzodiazepine-2-carboxamide::US12365687, Example 65

SMILES C[C@@H]1N=C(c2c(F)cccc2F)c2c(ccc(Cl)c2Cl)-n2nc(C(=O)NC[C@@H](C)O)nc21

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 759247   

LigandPNGBDBM759247((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...)
Affinity DataKi:  0.5nMAssay Description:Table 1 and 3: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]Fluma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

LigandPNGBDBM759247((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...)
Affinity DataKi:  5.80nMAssay Description:Table 2: Electrophysiological experiments were performed using the Roboocyte instrument (MultiChannelSystems, Reutlingen, Germany) on days 3 to 5 aft...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

LigandPNGBDBM759247((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...)
Affinity DataKi:  5.80nMAssay Description:Table 1 and 3: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]Fluma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

LigandPNGBDBM759247((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...)
Affinity DataKi:  492nMAssay Description:Table 1 and 3: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]Fluma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent