BDBM759293 (4S)-7,8-dichloro-6-(2,6-difluorophenyl)-1,4-dimethyl-4H-imidazo[1,2-a][1,4]benzodiazepine::US12365687, Example 111

SMILES Cc1cnc2n1-c1ccc(Cl)c(Cl)c1C(c1c(F)cccc1F)=N[C@H]2C

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 759293   

LigandPNGBDBM759293((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-1,4-dimet...)
Affinity DataKi:  1.24nMAssay Description:Table 1 and 3: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]Fluma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

LigandPNGBDBM759293((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-1,4-dimet...)
Affinity DataKi:  5.16nMAssay Description:Table 1 and 3: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]Fluma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

LigandPNGBDBM759293((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-1,4-dimet...)
Affinity DataKi:  5.20nMAssay Description:Table 2: Electrophysiological experiments were performed using the Roboocyte instrument (MultiChannelSystems, Reutlingen, Germany) on days 3 to 5 aft...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

LigandPNGBDBM759293((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-1,4-dimet...)
Affinity DataKi:  236nMAssay Description:Table 1 and 3: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]Fluma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent