BDBM759353 US12365696, Compound 5

SMILES COc3cc(N2CCC(N1CCN(C)CC1)CC2)ccc3Nc4ncc6c(n4)n(C)c5sc(C)nc5c(=O)n6C

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 759353   

TargetFocal adhesion kinase 1(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM759353(US12365696, Compound 5)
Affinity DataIC50: 18.3nMAssay Description:Using a bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514), 100 nL of 100× test compound in 100% DMSO was added. Followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/4/2025
Entry Details
US Patent

TargetFocal adhesion kinase 1(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM759353(US12365696, Compound 5)
Affinity DataIC50: 20.2nMAssay Description:Using a bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514), 100 nL of 100× test compound in 100% DMSO was added. Followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/4/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase 33(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM759353(US12365696, Compound 5)
Affinity DataIC50: 2.13E+3nMAssay Description:Using a bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514), 100 nL of 100× test compound in 100% DMSO was added. Followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/4/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase DCLK2(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM759353(US12365696, Compound 5)
Affinity DataIC50: 3.12E+3nMAssay Description:Using a bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514), 100 nL of 100× test compound in 100% DMSO was added. Followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/4/2025
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TNK1(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM759353(US12365696, Compound 5)
Affinity DataIC50: 3.17E+3nMAssay Description:Using a bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514), 100 nL of 100× test compound in 100% DMSO was added. Followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/4/2025
Entry Details
US Patent

TargetDual specificity protein kinase TTK(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM759353(US12365696, Compound 5)
Affinity DataIC50: 3.61E+3nMAssay Description:Using a bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514), 100 nL of 100× test compound in 100% DMSO was added. Followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/4/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase DCLK1(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM759353(US12365696, Compound 5)
Affinity DataIC50: 6.50E+3nMAssay Description:Using a bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514), 100 nL of 100× test compound in 100% DMSO was added. Followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/4/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase PLK1(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM759353(US12365696, Compound 5)
Affinity DataIC50: 8.28E+3nMAssay Description:Using a bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514), 100 nL of 100× test compound in 100% DMSO was added. Followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/4/2025
Entry Details
US Patent