BDBM759431 8-(6-cyclopropyl- 2,6- diazaspiro[3.3] heptan-2-yl)-6- methyl-N-(1- (methylsulfonyl) piperidin-4- yl)pyrido[3,4- d]pyrimidin- 2-amine::US20250235456, Compound 42

SMILES Cc1cc2cnc(NC3CCN(S(C)(=O)=O)CC3)nc2c(N2CC3(C2)CN(C2CC2)C3)n1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 759431   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM759431(8-(6-cyclopropyl- 2,6- diazaspiro[3.3] heptan-2-yl...)
Affinity DataIC50: 200nMAssay Description:The purpose of CDK2/Cyclin El assay is to evaluate the inhibition (% inhibition and IC50 values) of small molecule inhibitors by using a Luminescent ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/5/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM759431(8-(6-cyclopropyl- 2,6- diazaspiro[3.3] heptan-2-yl...)
Affinity DataIC50: 1.25E+3nMAssay Description:The purpose of the CDK6/Cyclin D3 assay is to evaluate the inhibition (% inhibition and IC50 values) in the presence of small molecule inhibitors by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/5/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Iambic Therapeutics

US Patent
LigandPNGBDBM759431(8-(6-cyclopropyl- 2,6- diazaspiro[3.3] heptan-2-yl...)
Affinity DataIC50: 2.00E+3nMAssay Description:The purpose of CDK1/Cyclin Bi assay is to evaluate the inhibition (% inhibition and IC50 values) of small molecule inhibitors by using a Luminescent ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/5/2025
Entry Details
US Patent