BDBM759791 (1S,5S)—N-(4-(1-ethyl-3-phenyl-1H-pyrazol-4-yl)-7-methoxypyrido[3,2-d]pyrimidin-6-yl)-3-oxabicyclo[3.1.0]hexane-1-carboxamide and (1R,5R)—N-(4-(1-ethyl-3-phenyl-1H-pyrazol-4-yl)-7-methoxypyrido[3,2-d]pyrimidin-6-yl)-3-oxabicyclo[3.1.0]hexane-1-carboxamide::US20250236608, Example 388

SMILES CCn6cc(c3ncnc4cc(OC)c(NC(=O)[C@]12COC[C@H]1C2)nc34)c(c5ccccc5)n6

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 759791   

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM759791((1S,5S)—N-(4-(1-ethyl-3-phenyl-1H-pyrazol-4-yl)-7-...)
Affinity DataIC50: 0.5nMAssay Description:Inhibitory effects of the compounds of the disclosure were measured in biochemical assays that measure the phosphorylation activity of EGFR enzyme ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/5/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R,C797S](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM759791((1S,5S)—N-(4-(1-ethyl-3-phenyl-1H-pyrazol-4-yl)-7-...)
Affinity DataIC50: 4.80nMAssay Description:Inhibitory effects of the compounds of the disclosure were measured in biochemical assays that measure the phosphorylation activity of EGFR enzyme ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/5/2025
Entry Details
US Patent