BDBM759812 (1S,5S)—N-(4-(1-(cyclopropylmethyl)-3-phenyl-1H-pyrazol-4-yl)-7-methoxypyrido[3,2-d]pyrimidin-6-yl)-3-methyl-3-azabicyclo[3.1.0]hexane-1-carboxamide and (1R,5R)—N-(4-(1-(cyclopropylmethyl)-3-phenyl-1H-pyrazol-4-yl)-7-methoxypyrido[3,2-d]pyrimidin-6-yl)-3-methyl-3-azabicyclo[3.1.0]hexane-1-carboxamide::US20250236608, Example 409

SMILES COc5cc4ncnc(c2cn(CC1CC1)nc2c3ccccc3)c4nc5NC(=O)[C@]67C[C@H]6CN(C)C7

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 759812   

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM759812((1S,5S)—N-(4-(1-(cyclopropylmethyl)-3-phenyl-1H-py...)
Affinity DataIC50: 0.600nMAssay Description:Inhibitory effects of the compounds of the disclosure were measured in biochemical assays that measure the phosphorylation activity of EGFR enzyme ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/5/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R,C797S](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM759812((1S,5S)—N-(4-(1-(cyclopropylmethyl)-3-phenyl-1H-py...)
Affinity DataIC50: 1nMAssay Description:Inhibitory effects of the compounds of the disclosure were measured in biochemical assays that measure the phosphorylation activity of EGFR enzyme ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/5/2025
Entry Details
US Patent