BDBM759844 US20250236608, Example 441

SMILES Cn1cc(-c2ccc3c(-c4c[nH]nc4-c4ccccc4)ncnc3c2)cn1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 759844   

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM759844(US20250236608, Example 441)
Affinity DataIC50: 0.700nMAssay Description:Inhibitory effects of the compounds of the disclosure were measured in biochemical assays that measure the phosphorylation activity of EGFR enzyme ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/5/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R,C797S](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM759844(US20250236608, Example 441)
Affinity DataIC50: 1.10nMAssay Description:Inhibitory effects of the compounds of the disclosure were measured in biochemical assays that measure the phosphorylation activity of EGFR enzyme ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/5/2025
Entry Details
US Patent