BDBM759849 (R)-1-(4-(1-(2,2-difluoroethyl)-3-phenyl-1H-pyrazol-4-yl)-7-(1-methyl-1H-pyrazol-4-yl)quinazolin-6-yl)ethan-1-ol and (S)-1-(4-(1-(2,2-difluoroethyl)-3-phenyl-1H-pyrazol-4-yl)-7-(1-methyl-1H-pyrazol-4-yl)quinazolin-6-yl)ethan-1-ol::US20250236608, Example 446

SMILES C[C@H](O)c1cc2c(-c3cn(CC(F)F)nc3-c3ccccc3)ncnc2cc1-c1cnn(C)c1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 759849   

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM759849((R)-1-(4-(1-(2,2-difluoroethyl)-3-phenyl-1H-pyrazo...)
Affinity DataIC50: 0.600nMAssay Description:Inhibitory effects of the compounds of the disclosure were measured in biochemical assays that measure the phosphorylation activity of EGFR enzyme ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/5/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R,C797S](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM759849((R)-1-(4-(1-(2,2-difluoroethyl)-3-phenyl-1H-pyrazo...)
Affinity DataIC50: 0.900nMAssay Description:Inhibitory effects of the compounds of the disclosure were measured in biochemical assays that measure the phosphorylation activity of EGFR enzyme ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/5/2025
Entry Details
US Patent