BDBM760718 5-(4-fluoro-2-methylphenyl)-4- hydroxy-6-methyl-N-[4-[(7-prop-1-en- 2-yl-1,5-naphthyridin-4- yl)oxy]phenyl]pyridine-3-carboxamide::US12371428, Compound 448

SMILES C=C(C)c1cnc2c(Oc3ccc(NC(=O)c4cnc(C)c(-c5ccc(F)cc5C)c4O)cc3)ccnc2c1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 760718   

TargetHepatocyte growth factor receptor(Human)
Exelixis

US Patent
LigandPNGBDBM760718(5-(4-fluoro-2-methylphenyl)-4- hydroxy-6-methyl-N-...)
Affinity DataIC50: 100nMAssay Description:Example D-1: Human Met (residues R974-S1390 with A1209G and V1290L, 3.4 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 M KKKGQEEEYVFIE (SE...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/10/2025
Entry Details
US Patent

TargetTyrosine-protein kinase Mer(Human)
Exelixis

US Patent
LigandPNGBDBM760718(5-(4-fluoro-2-methylphenyl)-4- hydroxy-6-methyl-N-...)
Affinity DataIC50: 100nMAssay Description:Example C-1: Human Mer (residues R557-E882 with H628Q and R794A, 0.7 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 30 mM NaCl, 250 μM GGMEDIY...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/10/2025
Entry Details
US Patent

TargetTyrosine-protein kinase receptor UFO(Human)
Exelixis

US Patent
LigandPNGBDBM760718(5-(4-fluoro-2-methylphenyl)-4- hydroxy-6-methyl-N-...)
Affinity DataIC50: 100nMAssay Description:Example A-1: Human Axl (residues H473-A894 with Q764R, 161 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 M KKSRGDYMTMQIG (SEQ ID NO:1), 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/10/2025
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Exelixis

US Patent
LigandPNGBDBM760718(5-(4-fluoro-2-methylphenyl)-4- hydroxy-6-methyl-N-...)
Affinity DataIC50: 200nMAssay Description:Example B-1: Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesiu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/10/2025
Entry Details
US Patent