BDBM761309 CHEM-US-00311 4-(2-((5-methoxy-7-methyl-1H-indol-4- yl)methyl)hexahydro-1H- spiro[cyclopenta[c]pyrrole-5,1''- cyclopropan]-1-yl)benzoic acid::US20250243186, Example 29

SMILES COc1cc(C(=O)O)c2[nH]ccc2c1CN1CC2CC3(CC3)CC2C1c1ccccc1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 761309   

TargetComplement factor B [470-764](Human)
Hansoh Bio

US Patent
LigandPNGBDBM761309(CHEM-US-00311 4-(2-((5-methoxy-7-methyl-1H-indol-4...)
Affinity DataKd:  7.03nMAssay Description:Table 2: Biacore 8 k instrument was primed using 1× PBS-P+ buffer before docking a Cytiva NTA chip. Recombinant human Factor B catalytic domain were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/12/2025
Entry Details
US Patent

TargetComplement factor B [470-764](Human)
Hansoh Bio

US Patent
LigandPNGBDBM761309(CHEM-US-00311 4-(2-((5-methoxy-7-methyl-1H-indol-4...)
Affinity DataIC50: 7.5nMAssay Description:Table 1: Factor B binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) tech...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/12/2025
Entry Details
US Patent

TargetComplement factor B [470-764](Human)
Hansoh Bio

US Patent
LigandPNGBDBM761309(CHEM-US-00311 4-(2-((5-methoxy-7-methyl-1H-indol-4...)
Affinity DataIC50: 43.7nMAssay Description:Table 1: Factor B binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) tech...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/12/2025
Entry Details
US Patent