BDBM761647 2-(3-fluorophenyl)-2-(3-(4-(4- methylpiperazin-1-yl)phenyl)- 5-oxo-5,7-dihydro-6H-pyrrolo- [3,4-b]pyridin-6-yl)-N-(thiazol- 2-yl)acetamide::US12377080, Compound 10

SMILES CN1CCN(c2ccc(-c3cnc4c(c3)C(=O)N(C(C(=O)Nc3nccs3)c3cccc(F)c3)C4)cc2)CC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 761647   

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM761647(2-(3-fluorophenyl)-2-(3-(4-(4- methylpiperazin-1-y...)
Affinity DataIC50: 4nMAssay Description:EGFR biochemical activity measurements were carried out using the homogeneous time-resolved fluorescence (HTRF) assay (Cisbio). Inhibitors and DMSO n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/17/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM761647(2-(3-fluorophenyl)-2-(3-(4-(4- methylpiperazin-1-y...)
Affinity DataIC50: 46nMAssay Description:EGFR biochemical activity measurements were carried out using the homogeneous time-resolved fluorescence (HTRF) assay (Cisbio). Inhibitors and DMSO n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/17/2025
Entry Details
US Patent