BDBM762515 US12378240, Compound 1.004::US20250387379, Compound 5.004

SMILES O=C(O)Cn1ccc2cncc(Nc3ccc(I)cc3F)c2c1=O

InChI Key InChIKey=DGLHJWQEOBFOEH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 762515   

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Nflection Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 762515BDBM762515(US12378240, Compound 1.004 | US20250387379, Compou...)
Affinity DataIC50: 1.50E+3nMAssay Description:Test compounds in 100% DMSO were screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold serial dilutions are conducted from the sta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/17/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 1(Human)
Nflection Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 762515BDBM762515(US12378240, Compound 1.004 | US20250387379, Compou...)
Affinity DataIC50: 1.50E+3nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent