BDBM764616 6-chloro-N-[5-chloro-1-(1- methylcyclopropyl)-1H-pyrazol- 4-yl]-7-[1-(oxetan-3- yl)piperidin-4-yl]quinazolin-2- amine::US12540131, Ex-4.56

SMILES CC1(n2ncc(Nc3ncc4cc(Cl)c(C5CCN(C6COC6)CC5)cc4n3)c2Cl)CC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 764616   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 764616BDBM764616(6-chloro-N-[5-chloro-1-(1- methylcyclopropyl)-1H-p...)
Affinity DataIC50: 0.631nMAssay Description:To assess phosphor-EGFR signaling, blots were probed with rabbit anti-Phospho-EGFR (Y1068) and mouse total anti-EGFR antibodies. Phospho-EGFR signal ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent