BDBM764617 6-chloro-N-(5-chloro-1- cyclopropyl-1H-pyrazol-4-yl)-7- (1-(oxetan-3-yl-3-d)piperidin-4- yl)quinazolin-2-amine::US12540131, Ex-4.57

SMILES [2H]C1(N2CCC(c3cc4nc(Nc5cnn(C6CC6)c5Cl)ncc4cc3Cl)CC2)COC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 764617   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 764617BDBM764617(6-chloro-N-(5-chloro-1- cyclopropyl-1H-pyrazol-4-y...)
Affinity DataIC50: 0.631nMAssay Description:To assess phosphor-EGFR signaling, blots were probed with rabbit anti-Phospho-EGFR (Y1068) and mouse total anti-EGFR antibodies. Phospho-EGFR signal ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent