BDBM764618 1-(5-chloro-4-((6-chloro-7-(1- (oxetan-3-yl-d5)piperidin-4- yl)quinazolin-2-yl)amino)-1H- pyrazol-1-yl)-2-methylpropan-2- ol::US12540131, Ex-4.58

SMILES [2H]C1([2H])OC([2H])([2H])C1([2H])N1CCC(c2cc3nc(Nc4cnn(CC(C)(C)O)c4Cl)ncc3cc2Cl)CC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 764618   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 764618BDBM764618(1-(5-chloro-4-((6-chloro-7-(1- (oxetan-3-yl-d5)pip...)
Affinity DataIC50: 0.631nMAssay Description:To assess phosphor-EGFR signaling, blots were probed with rabbit anti-Phospho-EGFR (Y1068) and mouse total anti-EGFR antibodies. Phospho-EGFR signal ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent