BDBM764619 1-(5-chloro-4-((6-chloro-7-(1- (oxetan-3-yl-3-d)piperidin-4- yl)quinazolin-2-yl)amino)-1H- pyrazol-1-yl)-2-methylpropan-2- ol::US12540131, Ex-4.59

SMILES [2H]C1(N2CCC(c3cc4nc(Nc5cnn(CC(C)(C)O)c5Cl)ncc4cc3Cl)CC2)COC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 764619   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 764619BDBM764619(1-(5-chloro-4-((6-chloro-7-(1- (oxetan-3-yl-3-d)pi...)
Affinity DataIC50: 0.631nMAssay Description:To assess phosphor-EGFR signaling, blots were probed with rabbit anti-Phospho-EGFR (Y1068) and mouse total anti-EGFR antibodies. Phospho-EGFR signal ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent