BDBM765144 2-[1H-benzimidazol-2-yl-(5-fluoro- 2-hydroxy-phenyl)-methyl]-6-[2- fluoro-4-(1-methyl-4- piperidyl)phenyl]isoindolin-1- one; formic acid::US12391671, Compound 029

SMILES CN1CCC(c2ccc(-c3ccc4c(c3)C(=O)N(C(c3nc5ccccc5[nH]3)c3cc(F)ccc3O)C4)c(F)c2)CC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 765144   

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM765144(2-[1H-benzimidazol-2-yl-(5-fluoro- 2-hydroxy-pheny...)
Affinity DataIC50: 0.600nMAssay Description:EGFR biochemical activity measurements were carried out using the homogeneous time-resolved fluorescence (HTRF) assay (Cisbio), inhibitors and DMSO n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM765144(2-[1H-benzimidazol-2-yl-(5-fluoro- 2-hydroxy-pheny...)
Affinity DataIC50: 2nMAssay Description:EGFR biochemical activity measurements were carried out using the homogeneous time-resolved fluorescence (HTRF) assay (Cisbio), inhibitors and DMSO n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent