BDBM765177 2-[1H-benzimidazol-2-yl-(5-fluoro- 2-hydroxy-phenyl)-methyl]-6-[4-(4- piperidyl)-phenyl]isoindolin-1-one; hydrochloride::US12391671, Compound 062

SMILES O=C1c2cc(-c3ccc(C4CCNCC4)cc3)ccc2CN1C(c1nc2ccccc2[nH]1)c1cc(F)ccc1O

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 765177   

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM765177(2-[1H-benzimidazol-2-yl-(5-fluoro- 2-hydroxy-pheny...)
Affinity DataIC50: 0.700nMAssay Description:EGFR biochemical activity measurements were carried out using the homogeneous time-resolved fluorescence (HTRF) assay (Cisbio), inhibitors and DMSO n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM765177(2-[1H-benzimidazol-2-yl-(5-fluoro- 2-hydroxy-pheny...)
Affinity DataIC50: 3nMAssay Description:EGFR biochemical activity measurements were carried out using the homogeneous time-resolved fluorescence (HTRF) assay (Cisbio), inhibitors and DMSO n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent