BDBM765188 3-[1H-benzimidazol-2-yl-(5-fluoro- 2-hydroxy-phenyl)methyl]-5-ethyl- 6-[4-(1-methyl-4-piperidyl)phenyl]- quinazolin-4-one; dihydrochloride::US12391671, Compound 074

SMILES CCc1c(-c2ccc(C3CCN(C)CC3)cc2)ccc2ncn(C(c3nc4ccccc4[nH]3)c3cc(F)ccc3O)c(=O)c12

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 765188   

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM765188(3-[1H-benzimidazol-2-yl-(5-fluoro- 2-hydroxy-pheny...)
Affinity DataIC50: 1nMAssay Description:EGFR biochemical activity measurements were carried out using the homogeneous time-resolved fluorescence (HTRF) assay (Cisbio), inhibitors and DMSO n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM765188(3-[1H-benzimidazol-2-yl-(5-fluoro- 2-hydroxy-pheny...)
Affinity DataIC50: 2nMAssay Description:EGFR biochemical activity measurements were carried out using the homogeneous time-resolved fluorescence (HTRF) assay (Cisbio), inhibitors and DMSO n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent