BDBM765193 2-[1H-benzimidazol-2-yl-(5-fluoro- 2-hydroxy-phenyl)methyl]-6-[4-(3- methyl-3-azabicyclo[4.1.0]heptan- 6-yl)phenyl]isoindolin-1- one; dihydrochloride::US12391671, Compound 079

SMILES CN1CCC2(c3ccc(-c4ccc5c(c4)C(=O)N(C(c4nc6ccccc6[nH]4)c4cc(F)ccc4O)C5)cc3)CC2C1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 765193   

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM765193(2-[1H-benzimidazol-2-yl-(5-fluoro- 2-hydroxy-pheny...)
Affinity DataIC50: 0.800nMAssay Description:EGFR biochemical activity measurements were carried out using the homogeneous time-resolved fluorescence (HTRF) assay (Cisbio), inhibitors and DMSO n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM765193(2-[1H-benzimidazol-2-yl-(5-fluoro- 2-hydroxy-pheny...)
Affinity DataIC50: 3nMAssay Description:EGFR biochemical activity measurements were carried out using the homogeneous time-resolved fluorescence (HTRF) assay (Cisbio), inhibitors and DMSO n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent