BDBM765221 US12391671, Compound 110

SMILES CN1CCC2(c3ccc(-c4cc(F)c5c(=O)n(C(c6nc7ccccc7[nH]6)c6cc(F)ccc6O)ccc5c4)cc3)CC2C1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 765221   

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM765221(US12391671, Compound 110)
Affinity DataIC50: 0.600nMAssay Description:EGFR biochemical activity measurements were carried out using the homogeneous time-resolved fluorescence (HTRF) assay (Cisbio), inhibitors and DMSO n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM765221(US12391671, Compound 110)
Affinity DataIC50: 3nMAssay Description:EGFR biochemical activity measurements were carried out using the homogeneous time-resolved fluorescence (HTRF) assay (Cisbio), inhibitors and DMSO n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent