BDBM765358 US12391687, Example 29

SMILES CN1CC(n2cc(-c3cnc4[nH]nc(N5C[C@@H](F)C[C@@H]5c5cc(F)ccc5F)c4c3)cn2)C1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 765358   

TargetHigh affinity nerve growth factor receptor(Human)
Shanghai Ennovabio Pharmaceuticals

US Patent
LigandPNGBDBM765358(US12391687, Example 29)
Affinity DataIC50: 1nMAssay Description:Table 1: Experimental MethodThe tested compounds were subjected to 3-fold serial dilution to reach a final concentration of 1 μM to 0.05 nM (10 conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Shanghai Ennovabio Pharmaceuticals

US Patent
LigandPNGBDBM765358(US12391687, Example 29)
Affinity DataIC50: 1nMAssay Description:Table 1: Experimental MethodThe tested compounds were subjected to 3-fold serial dilution to reach a final concentration of 1 μM to 0.05 nM (10 conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Shanghai Ennovabio Pharmaceuticals

US Patent
LigandPNGBDBM765358(US12391687, Example 29)
Affinity DataIC50: 1nMAssay Description:Table 1: Experimental MethodThe tested compounds were subjected to 3-fold serial dilution to reach a final concentration of 1 μM to 0.05 nM (10 conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Shanghai Ennovabio Pharmaceuticals

US Patent
LigandPNGBDBM765358(US12391687, Example 29)
Affinity DataIC50: 10nMAssay Description:Table 3: Experimental MaterialsThe recombinant human TRKA (G595R), TRKA (G667C) and TRKC (G623R) proteins were purchased from SignalChem. HTRF kinEAS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent