BDBM765368 3-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-1H-pyrazolo[3,4-b]pyridine-5-carbohydrazide::US12391687, Example 39

SMILES NNC(=O)c1cnc2[nH]nc(N3C[C@@H](F)C[C@@H]3c3cc(F)ccc3F)c2c1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 765368   

TargetNT-3 growth factor receptor(Human)
Shanghai Ennovabio Pharmaceuticals

US Patent
LigandPNGBDBM765368(3-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolid...)
Affinity DataIC50: 1nMAssay Description:Table 1: Experimental MethodThe tested compounds were subjected to 3-fold serial dilution to reach a final concentration of 1 μM to 0.05 nM (10 conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Shanghai Ennovabio Pharmaceuticals

US Patent
LigandPNGBDBM765368(3-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolid...)
Affinity DataIC50: 1nMAssay Description:Table 1: Experimental MethodThe tested compounds were subjected to 3-fold serial dilution to reach a final concentration of 1 μM to 0.05 nM (10 conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Shanghai Ennovabio Pharmaceuticals

US Patent
LigandPNGBDBM765368(3-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolid...)
Affinity DataIC50: 1nMAssay Description:Table 1: Experimental MethodThe tested compounds were subjected to 3-fold serial dilution to reach a final concentration of 1 μM to 0.05 nM (10 conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent