BDBM765372 ((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)(4-(((1R,2R)-2-hydroxycyclopentyl)amino)-1H-pyrazolo[3,4-b]pyridin-3-yl)methanone::US12391687, Example 43

SMILES O=C(c1n[nH]c2nccc(N[C@@H]3CCC[C@H]3O)c12)N1C[C@@H](F)C[C@@H]1c1cc(F)ccc1F

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 765372   

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Shanghai Ennovabio Pharmaceuticals

US Patent
LigandPNGBDBM765372(((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin...)
Affinity DataIC50: 1nMAssay Description:Table 3: Experimental MaterialsThe recombinant human TRKA (G595R), TRKA (G667C) and TRKC (G623R) proteins were purchased from SignalChem. HTRF kinEAS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Shanghai Ennovabio Pharmaceuticals

US Patent
LigandPNGBDBM765372(((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin...)
Affinity DataIC50: 1nMAssay Description:Table 1: Experimental MethodThe tested compounds were subjected to 3-fold serial dilution to reach a final concentration of 1 μM to 0.05 nM (10 conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Shanghai Ennovabio Pharmaceuticals

US Patent
LigandPNGBDBM765372(((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin...)
Affinity DataIC50: 1nMAssay Description:Table 1: Experimental MethodThe tested compounds were subjected to 3-fold serial dilution to reach a final concentration of 1 μM to 0.05 nM (10 conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Shanghai Ennovabio Pharmaceuticals

US Patent
LigandPNGBDBM765372(((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin...)
Affinity DataIC50: 1nMAssay Description:Table 1: Experimental MethodThe tested compounds were subjected to 3-fold serial dilution to reach a final concentration of 1 μM to 0.05 nM (10 conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent