BDBM766257 N-(1-(bicyclo[1.1.1]pentan-1-yl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-7-methylquinoxalin-6-amine ::US20250263753, Compound 49

SMILES Cc1cc2nccnc2cc1Nc1ncc2c(C)nn(C34CC(C3)C4)c2n1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 766257   

TargetDNA-dependent protein kinase catalytic subunit(Human)
Juno Therapeutics

US Patent
LigandPNGBDBM766257(N-(1-(bicyclo[1.1.1]pentan-1-yl)-3-methyl-1H-pyraz...)
Affinity DataIC50: 1nMAssay Description:Reagent: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.01% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/3/2025
Entry Details
US Patent

TargetSerine-protein kinase ATM(Human)
Juno Therapeutics

US Patent
LigandPNGBDBM766257(N-(1-(bicyclo[1.1.1]pentan-1-yl)-3-methyl-1H-pyraz...)
Affinity DataIC50: 55nMAssay Description:The assay detects kinase activity by antibody based HTRF assay. The GST-tagged p53 protein serves as substrate and Eu-labeled-antibody with specific ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/3/2025
Entry Details
US Patent

LigandPNGBDBM766257(N-(1-(bicyclo[1.1.1]pentan-1-yl)-3-methyl-1H-pyraz...)
Affinity DataIC50: 550nMAssay Description:A solution was prepared containing 0.2 nM Anti-HIS-Terbium (Cisbio, 64CUSTAZU), 3.7 nM designed-probe and 1.0 nM His-PIK3CA/PIK3R1 (p110 alpha/p85 al...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/3/2025
Entry Details
US Patent

LigandPNGBDBM766257(N-(1-(bicyclo[1.1.1]pentan-1-yl)-3-methyl-1H-pyraz...)
Affinity DataIC50: 550nMAssay Description:A solution was prepared containing 0.2 nM Anti-HIS-Terbium (Cisbio, 64CUSTAZU), 40 nM designed-probe and 1.0 nM His-PIK3CD/PIK3R1 (p110 delta/p85 alp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/3/2025
Entry Details
US Patent