BDBM766266 8-(3-fluorobicyclo[1.1.1]pentan-1-yl)-5-methyl-2-((6-methylbenzo[c][1,2,5]thiadiazol-5-yl)amino)-7,8-dihydropteridin-6(5H)-one ::US20250263753, Compound 58

SMILES Cc1cc2nsnc2cc1Nc1ncc2c(n1)N(C13CC(F)(C1)C3)CC(=O)N2C

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 766266   

TargetDNA-dependent protein kinase catalytic subunit(Human)
Juno Therapeutics

US Patent
LigandPNGBDBM766266(8-(3-fluorobicyclo[1.1.1]pentan-1-yl)-5-methyl-2-(...)
Affinity DataIC50: 1nMAssay Description:Reagent: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.01% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/3/2025
Entry Details
US Patent

TargetSerine-protein kinase ATM(Human)
Juno Therapeutics

US Patent
LigandPNGBDBM766266(8-(3-fluorobicyclo[1.1.1]pentan-1-yl)-5-methyl-2-(...)
Affinity DataIC50: 550nMAssay Description:The assay detects kinase activity by antibody based HTRF assay. The GST-tagged p53 protein serves as substrate and Eu-labeled-antibody with specific ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/3/2025
Entry Details
US Patent

LigandPNGBDBM766266(8-(3-fluorobicyclo[1.1.1]pentan-1-yl)-5-methyl-2-(...)
Affinity DataIC50: 1.00E+3nMAssay Description:A solution was prepared containing 0.2 nM Anti-HIS-Terbium (Cisbio, 64CUSTAZU), 3.7 nM designed-probe and 1.0 nM His-PIK3CA/PIK3R1 (p110 alpha/p85 al...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/3/2025
Entry Details
US Patent