BDBM766269 8-(4-hydroxybicyclo[2.2.1]heptan-1-yl)-5-methyl-2-((7-methylcinnolin-6-yl)amino)-7,8-dihydropteridin-6(5H)-one ::US20250263753, Compound 61
SMILES Cc1cc2nnccc2cc1Nc1ncc2c(n1)N(C13CCC(O)(CC1)C3)CC(=O)N2C
InChI Key
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 766269
Affinity DataIC50: 1nMAssay Description:Reagent: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.01% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:The assay detects kinase activity by antibody based HTRF assay. The GST-tagged p53 protein serves as substrate and Eu-labeled-antibody with specific ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha(Human)
Juno Therapeutics
US Patent
Juno Therapeutics
US Patent
Affinity DataIC50: 55nMAssay Description:A solution was prepared containing 0.2 nM Anti-HIS-Terbium (Cisbio, 64CUSTAZU), 3.7 nM designed-probe and 1.0 nM His-PIK3CA/PIK3R1 (p110 alpha/p85 al...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Juno Therapeutics
US Patent
Juno Therapeutics
US Patent
Affinity DataIC50: 550nMAssay Description:A solution was prepared containing 0.2 nM Anti-HIS-Terbium (Cisbio, 64CUSTAZU), 40 nM designed-probe and 1.0 nM His-PIK3CD/PIK3R1 (p110 delta/p85 alp...More data for this Ligand-Target Pair