BDBM766694 US12398141, Example H39

SMILES N#Cc1cnc2[nH]ccc2c1N1CC2CN(C(=O)NCC(F)(F)F)CC21

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 766694   

TargetTyrosine-protein kinase JAK1(Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandPNGBDBM766694(US12398141, Example H39)
Affinity DataIC50: 0.350nMAssay Description:JAK1 LANCE® Ultra assay, JAK2 LANCE® Ultra assay and JAK3 LANCE® Ultra assay were used to carry out the test separately, and kits of the above assays...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/5/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandPNGBDBM766694(US12398141, Example H39)
Affinity DataIC50: 21nMAssay Description:JAK1 LANCE® Ultra assay, JAK2 LANCE® Ultra assay and JAK3 LANCE® Ultra assay were used to carry out the test separately, and kits of the above assays...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/5/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandPNGBDBM766694(US12398141, Example H39)
Affinity DataIC50: 150nMAssay Description:JAK1 LANCE® Ultra assay, JAK2 LANCE® Ultra assay and JAK3 LANCE® Ultra assay were used to carry out the test separately, and kits of the above assays...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/5/2025
Entry Details
US Patent