BDBM766731 US12398141, Example H76

SMILES CC[C@@H]1CN(S(=O)(=O)CCC(F)(F)F)C[C@@H]1Nc1c(C#N)cnc2[nH]ccc12

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 766731   

TargetTyrosine-protein kinase JAK1(Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandPNGBDBM766731(US12398141, Example H76)
Affinity DataIC50: 0.950nMAssay Description:JAK1 LANCE® Ultra assay, JAK2 LANCE® Ultra assay and JAK3 LANCE® Ultra assay were used to carry out the test separately, and kits of the above assays...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/5/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandPNGBDBM766731(US12398141, Example H76)
Affinity DataIC50: 7.80nMAssay Description:JAK1 LANCE® Ultra assay, JAK2 LANCE® Ultra assay and JAK3 LANCE® Ultra assay were used to carry out the test separately, and kits of the above assays...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/5/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandPNGBDBM766731(US12398141, Example H76)
Affinity DataIC50: 91nMAssay Description:JAK1 LANCE® Ultra assay, JAK2 LANCE® Ultra assay and JAK3 LANCE® Ultra assay were used to carry out the test separately, and kits of the above assays...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/5/2025
Entry Details
US Patent