BDBM766902 N-(5-(7''-Fluoro-3''-methyl-2''-oxo-2'',3''-dihydrospiro[cyclobutane-1,1''-pyrrolo[2,3-c]quinolin]-8''-yl)-2-(2-(isopropylamino)ethoxy)pyridin-3-yl)propane-2-sulfonamide::US20250268873, Compound 568

SMILES CC(C)NCCOC1=NCC(C2=CC3C4=C(C=NC3CC2F)N(C)C(=O)C42CCC2)C=C1NS(=O)(=O)C(C)C

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 766902   

TargetDNA-dependent protein kinase catalytic subunit(Human)
XRAD Therapeutics

US Patent
LigandPNGBDBM766902(N-(5-(7'-Fluoro-3'-methyl-2'-oxo-2',3'-dihydrospir...)
Affinity DataIC50: 0.790nMAssay Description:On day one, a 96-well plate (ThermoFisher, Cat #: 442404) was coated with GST-p53 (1-101) peptide (purified by Pharmaron, BCS department) by diluting...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/8/2025
Entry Details
US Patent

LigandPNGBDBM766902(N-(5-(7'-Fluoro-3'-methyl-2'-oxo-2',3'-dihydrospir...)
Affinity DataIC50: 18nMAssay Description:PI3Kα and PI3Kδ Kinase reactions were performed in a 5 μL volume in low-volume 384-well plates. Typically, PerkinElmer model 6008280 plates were used...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/8/2025
Entry Details
US Patent

LigandPNGBDBM766902(N-(5-(7'-Fluoro-3'-methyl-2'-oxo-2',3'-dihydrospir...)
Affinity DataIC50: 54nMAssay Description:PI3Kα and PI3Kδ Kinase reactions were performed in a 5 μL volume in low-volume 384-well plates. Typically, PerkinElmer model 6008280 plates were used...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/8/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
XRAD Therapeutics

US Patent
LigandPNGBDBM766902(N-(5-(7'-Fluoro-3'-methyl-2'-oxo-2',3'-dihydrospir...)
Affinity DataIC50: 100nMAssay Description:mTOR Kinase reactions were performed in a 10 μL volume in low-volume 384-well plates. Typically, PerkinElmer model 6008260 plates were used. The comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/8/2025
Entry Details
US Patent