BDBM766905 N-(2-(3- (Dimethylamino)a- zetidin-1-yl)-5-(3''- methyl-2''-oxo- 2'',3''- dihydrospiro[cyclo- butane-1,1''- pyrrolo[2,3- c]quinolin]-8''- yl)pyridin-3- yl)methanesulfona- mide hydrochloride::US20250268873, Compound 574
SMILES CN1C(=O)C2(CCC2)c2c1cnc1ccc(-c3cnc(N4CC(N(C)C)C4)c(NS(C)(=O)=O)c3)cc21
InChI Key
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 766905
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
XRAD Therapeutics
US Patent
XRAD Therapeutics
US Patent
Affinity DataIC50: 0.120nMAssay Description:PI3Kα and PI3Kδ Kinase reactions were performed in a 5 μL volume in low-volume 384-well plates. Typically, PerkinElmer model 6008280 plates were used...More data for this Ligand-Target Pair
Affinity DataIC50: 1.03nMAssay Description:On day one, a 96-well plate (ThermoFisher, Cat #: 442404) was coated with GST-p53 (1-101) peptide (purified by Pharmaron, BCS department) by diluting...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
XRAD Therapeutics
US Patent
XRAD Therapeutics
US Patent
Affinity DataIC50: 3nMAssay Description:PI3Kα and PI3Kδ Kinase reactions were performed in a 5 μL volume in low-volume 384-well plates. Typically, PerkinElmer model 6008280 plates were used...More data for this Ligand-Target Pair
Affinity DataIC50: 19.9nMAssay Description:mTOR Kinase reactions were performed in a 10 μL volume in low-volume 384-well plates. Typically, PerkinElmer model 6008260 plates were used. The comp...More data for this Ligand-Target Pair