BDBM767012 US20250268897, Compound BLU-667

SMILES COC1(C(=O)N[C@H](C)c2ccc(-n3cc(F)cn3)nc2)CCC(c2nc(C)cc(Nc3cc(C)[nH]n3)n2)CC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 767012   

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810S](Human)
Sichuan Kelun-Biotech Biopharmaceutical Co.

US Patent
LigandPNGBDBM767012(US20250268897, Compound BLU-667)
Affinity DataIC50: 1.77nMAssay Description:The three drug-resistant mutant RET enzymes were each pre-incubated with different concentrations of test compounds (in the inhibition rate test of t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/8/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810C](Human)
Sichuan Kelun-Biotech Biopharmaceutical Co.

US Patent
LigandPNGBDBM767012(US20250268897, Compound BLU-667)
Affinity DataIC50: 48.8nMAssay Description:The three drug-resistant mutant RET enzymes were each pre-incubated with different concentrations of test compounds (in the inhibition rate test of t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/8/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Sichuan Kelun-Biotech Biopharmaceutical Co.

US Patent
LigandPNGBDBM767012(US20250268897, Compound BLU-667)
Affinity DataIC50: 168nMAssay Description:The three drug-resistant mutant RET enzymes were each pre-incubated with different concentrations of test compounds (in the inhibition rate test of t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/8/2025
Entry Details
US Patent